2020.08.18
Summary:The automatic batching system uses traditional Chinese medicine process control technology, computer technology, information technology, modern detection technology, APC technology and expert systems to provide an overall automated solution.
Chinese medicine extraction process complete sets of special equipment is a set of production control, optimization, scheduling, management and operation in one of the integrated automation system, its main task is to achieve real-time monitoring of the production process, fault diagnosis, quality control and scheduling optimization; to deepen the comprehensive integration of the core business of the production and manufacturing and operations management, purchasing and sales; for the pharmaceutical industry to establish a state of the production process monitoring, quality control, quick detection It also establishes state monitoring, quality control and rapid testing systems for the pharmaceutical industry, and improves the whole life cycle management system of product quality and safety.
The production process of traditional Chinese medicine extraction is a typical intermittent production process that produces a certain amount of products according to a given formula in accordance with GMP specifications. Its main characteristics are: small batch, multi-species, characterized by: discontinuity of material flow, non-stationarity of materials and equipment, product and its process uncertainty and dynamic scheduling and allocation of equipment resources. Discontinuity refers to the material input and output is intermittent, unit operation is sequential, equipment operation is intermittent, non-stationarity refers to the production process of materials and equipment are often in a state of change. Uncertainty refers to the need to produce different products according to market demand, and the addition of new products.
Chinese medicine weighing and batching system mainly includes: multi-functional extraction reactor, hot reflux extraction device, external circulation vacuum decompression concentrator, internal circulation vacuum decompression concentrator, spherical concentrator, stirring precipitation reactor, cold precipitation reactor, centrifuge, plate and frame filter, distillation tower, solvent configuration reactor, decolorization reactor, crystallization reactor, macroporous resin adsorption and elution device, membrane separation/membrane concentration device, supercritical membrane separation/membrane concentration device, supercritical extraction device, microwave extraction device, ultrasonic extraction device, storage reactor and so on.
The whole process of automatic dosage system is to realize the most reasonable mode of pharmaceutical production automation, the production of drugs is a very typical "batch process" characteristics and flexible management requirements of the batch production process. Each batch number, each batch, each production and management of batch records, batch files, often represents the "batch" of all the quality attributes of the drug. The quality of the drug life cycle is often controlled and managed according to the "batch". Production of raw materials and equipment resources are relatively stable conditions, once the type of drug production, process requirements and production plan changes, to achieve the production of drugs in the batch process of automatic, rapid, effective and flexible adjustment.
Extraction reactor control: extraction reactor is the most commonly used equipment for solid-liquid extraction of traditional Chinese medicine, which is divided into dynamic extraction reactor and static extraction reactor, and more than one extraction reactor can constitute a set of extraction device. Its basic operation and control include: test leakage control, quantitative solvent, artificial feeding, temperature control, constant temperature timing, boiling timing, timing cycle, timing mixing, discharge control, alcohol reflux, aromatic oil recovery, slagging control, blowback control, direct steam control, cleaning control, cooking reactor, alarm, safety chain.
External circulation single-effect evaporator control: external circulation single-effect evaporator, composed of heater, evaporator, separator, etc., mainly used in pharmaceutical, chemical, food, dairy and other fields of alcohol recovery and concentration, can also be used for material concentration. The basic operation and control include: quantitative feeding, heater steam pressure/temperature control, evaporator vacuum control, cooling water flow detection, cooling water temperature detection, density detection and paste collection control, automatic defoaming, liquid level control, condensate discharge or solvent recovery control, cleaning control, boil reactor control, etc.
Double or multi-effect concentrator control: Double or multi-effect concentrator, consisting of two or more heaters, evaporator, separator, etc., is suitable for material concentration in the fields of pharmacy, chemical industry, foodstuffs, dairy products and so on. The basic operation and control include: quantitative feeding, heater steam pressure (temperature) control, evaporator final vacuum control, cooling water flow detection, cooling water temperature detection, pouring control, density detection and paste collection control, automatic defoaming, liquid level control, condensate discharge control, cleaning control, boil reactor control, etc.
